| Identification | Back Directory | [Name]
L 648051 | [CAS]
91541-18-3 | [Synonyms]
L48051
4-Apsob
L 648051
4-[[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfonyl]-γ-oxobenzenebutanoic acid | [Molecular Formula]
C24H28O8S | [MDL Number]
MFCD00869350 | [MOL File]
91541-18-3.mol | [Molecular Weight]
476.539 |
| Hazard Information | Back Directory | [Uses]
L-648051 is a leukotriene D4 receptor (LTD4) antagonist. L-648051 plays an important role in arrhythmias[1]. | [in vivo]
L-648051 (5-10 mg/kg; iv; once) significantly prevents the incidence of ventricular fibrillation[1]. | Animal Model: | Guinea-pigs treated with Digoxin (HY-B1049)[1] | | Dosage: | 5 mg/kg and 10 mg/kg | | Administration: | intravenous injection | | Result: | Significantly prevented the incidence of ventricular fibrillation.
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| [References]
[1] S G?k, et al. Effects of a leukotriene D4 receptor antagonist, L-648,051, and a dual inhibitor lypoxygenase and cyclooxygenase, BW-755C, on digoxin-induced arrhythmias in guinea-pigs. Arch Int Pharmacodyn Ther. 1993 Jan-Feb:321:72-80. PMID:8391788 |
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