| Identification | Back Directory | [Name]
RA-9 | [CAS]
919091-63-7 | [Synonyms]
4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)- | [Molecular Formula]
C19H15N3O5 | [MDL Number]
MFCD28400615 | [MOL File]
919091-63-7.mol | [Molecular Weight]
365.34 |
| Chemical Properties | Back Directory | [Melting point ]
230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8)) | [Boiling point ]
588.5±50.0 °C(Predicted) | [density ]
1.414±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
5.13±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells[1]. | [Biological Activity]
RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines. | [in vivo]
RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer. < td class="col1 fwb"> Animal Model: | Six-week-old female immunodeficient (NCr nu/nu) mice | | Dosage: | 5 mg/kg | | Administration: | Ip; one-day on, two-days off | | Result: | Significant reduction in tumor burden at day 12. | | [target]
| Target | Value | DUBs
() | [storage]
Store at -20°C | [References]
[1] Coughlin K, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res. 2014;20(12):3174-3186. DOI:10.1158/1078-0432.CCR-13-2658 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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Tags:919091-63-7
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