| Identification | Back Directory | [Name]
Benzeneacetic acid, 3-chloro-5-[2-[4-(1-pyrrolidinyl)-1-[5-(trifluoromethyl)thiazolo[5,4-b]pyridin-2-yl]-4-piperidinyl]ethoxy]- | [CAS]
928023-21-6 | [Synonyms]
PPARδ agonist 9 Benzeneacetic acid, 3-chloro-5-[2-[4-(1-pyrrolidinyl)-1-[5-(trifluoromethyl)thiazolo[5,4-b]pyridin-2-yl]-4-piperidinyl]ethoxy]- | [Molecular Formula]
C26H28ClF3N4O3S | [MOL File]
928023-21-6.mol | [Molecular Weight]
569.04 |
| Hazard Information | Back Directory | [Uses]
PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%)[1]. | [References]
[1] Kato T, et al. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure. J Med Chem. 2023 Aug 24;66(16):11428-11446.. DOI:10.1021/acs.jmedchem.3c00932 |
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Biorbyt Ltd.
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http://www.biorbyt.com |
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