| Identification | Back Directory | [Name]
DPPE | [CAS]
92981-78-7 | [Synonyms]
YMB1002
BMY 33419
BMS 217380-01
DPPE hydrochloride
Tesmilifine hydrochloride
TXLHNFOLHRXMAU-UHFFFAOYSA-N
TesMilifene (hydrochloride)
[2-(4-Benzyl-phenoxy)-ethyl]-diethyl-amine hydrochloride
N,N-Diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine hydrochloride | [Molecular Formula]
C19H26ClNO | [MDL Number]
MFCD11114012 | [MOL File]
92981-78-7.mol | [Molecular Weight]
319.87 |
| Chemical Properties | Back Directory | [Melting point ]
156-158° | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble16mg/mL | [form ]
white powder | [pka]
10.9(at 25℃) | [color ]
white | [Water Solubility ]
H2O: 16mg/mL |
| Hazard Information | Back Directory | [Uses]
Tesmilifene hydrochloride is an antihistamine agent and a chemical sensitizer. Tesmilifene hydrochloride targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene hydrochloride overcomes multidrug resistance[1]. | [Biological Activity]
DPPE is a potentselective ligand of the microsomal anti-estrogen binding site. DPPE is a tamoxifen derivataive th at binds with high affinity to the anti-estrogen binding sitebut unlike tamoxifendoes not bind to the estrogen receptor. DPPE sensitizes MDR tumor cells to chemotherapy and also inhibits histamine binding at the intracellular histamine site. | [References]
[1] Brandes LJ. N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer. Hum Exp Toxicol. 2008 Feb;27(2):143-7. DOI:10.1177/0960327108090751 |
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Merck KGaA
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www.sigmaaldrich.cn |
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TargetMol
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www.targetmol.cn/ |
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