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932744-62-2

932744-62-2 Structure

932744-62-2 Structure
IdentificationBack Directory
[Name]

L-Ornithinamide, N-[2-[[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]ethyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-[[(4-methyl-1-piperazinyl)carbonyl]oxy]-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]amino]carbonyl]phenyl]-
[CAS]

932744-62-2
[Synonyms]

MB-VC-MGBA
L-Ornithinamide, N-[2-[[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]ethyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-[[(4-methyl-1-piperazinyl)carbonyl]oxy]-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]amino]carbonyl]phenyl]-
[Molecular Formula]

C56H65ClN12O10
[MOL File]

932744-62-2.mol
[Molecular Weight]

1101.64
Chemical PropertiesBack Directory
[Boiling point ]

1250.5±65.0 °C(Predicted)
[density ]

1.375±0.06 g/cm3(Predicted)
[pka]

13.75±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC[1].
[IC 50]

Duocarmycins
[References]

[1] Samantha Congreve, et al. Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs.
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