| Identification | Back Directory | [Name]
Trimidox (hydrochloride) Exclusive | [CAS]
95933-75-8 | [Synonyms]
Reaxys ID: 25792093
KBKNXSNOQYLIRI-UHFFFAOYSA-N
Trimidox (hydrochloride) Exclusive | [Molecular Formula]
C7H9ClN2O4 | [MDL Number]
MFCD18382080 | [MOL File]
95933-75-8.mol | [Molecular Weight]
220.61 |
| Hazard Information | Back Directory | [Description]
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM.1 | [Uses]
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM[1]. | [References]
1. Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells Blood 84(12),4316-4321(1994).
2. Kanno, S.I., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells Basic Clin. Pharmacol. Toxicol. 98,44-50(2006). |
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