| Identification | Back Directory | [Name]
2'-deoxyuridine 5'-monophosphate | [CAS]
964-26-1 | [Synonyms]
dUMP·H2
2'-deoxyuridylic acid
2'-Deoxy-5'-uridylic acid
5'-Uridylic acid, 2'-deoxy-
2'-Deoxyuridine 5'-phosphate
2''-Deoxyuridine-5''-monophosphoric acid
2'-Deoxyuridine-5'-monophosphate free acid
[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxyphosphonic acid
(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | [EINECS(EC#)]
213-518-9 | [Molecular Formula]
C9H13N2O8P | [MOL File]
964-26-1.mol | [Molecular Weight]
308.18 |
| Hazard Information | Back Directory | [Uses]
2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1]. | [Definition]
ChEBI: A pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having uracil as the nucleobase. | [References]
[1] Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. DOI:10.1021/bi060152s
[2] Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5(6):150015. DOI:10.1098/rsob.150015 |
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