| Identification | Back Directory | [Name]
1-BOC-1,7-DIAMINOHEPTANE | [CAS]
99733-18-3 | [Synonyms]
Boc-DAHpt
1-BOC-1,7-DIAMINOHEPTANE
N-Boc-1,7-Diaminoheptane
N1-Boc-1,7-heptanediamine
N1-BOC-1,7-DIAMINOHEPTANE
tert-Butyl 2,8-diaminooctanoate
TERT-BUTYL 7-AMINOHEPTYLCARBAMATE
1,7-Diaminoheptane, N1-BOC protected
Heptane-1,7-diamine, N-Boc protected
tert-Butyl (7-aminohept-1-yl)carbamate
N-t-Butyloxycarbonyl-1,7-diaminoheptane
1,7-Diaminoheptane, N1-BOC protected 95%
Heptane-1,7-diamine, N-BOC protected 95%
N-(tert-butoxycarbonyl)-1,7-heptanediamine
Carbamic acid, N-(7-aminoheptyl)-, 1,1-dimethylethyl ester
tert-Butyl (7-aminohept-1-yl)carbamate, 1,7-Diaminoheptane, N-BOC protected
tert-Butyl 7-aminoheptylcarbamate
1-Boc-1,7-diaminoheptane
1,7-Diaminoheptane N1-boc protected | [Molecular Formula]
C12H26N2O2 | [MDL Number]
MFCD02094498 | [MOL File]
99733-18-3.mol | [Molecular Weight]
230.35 |
| Chemical Properties | Back Directory | [Melting point ]
39-41 °C | [Boiling point ]
340.9±25.0 °C(Predicted) | [density ]
0.949±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
liquid | [pka]
12.94±0.46(Predicted) | [color ]
Colourless | [InChI]
1S/C12H26N2O2/c1-12(2,3)16-11(15)14-10-8-6-4-5-7-9-13/h4-10,13H2,1-3H3,(H,14,15) | [InChIKey]
DTJYPERGUPPXRU-UHFFFAOYSA-N | [SMILES]
O=C(OC(C)(C)C)NCCCCCCCN |
| Hazard Information | Back Directory | [Description]
tert-Butyl (7-aminoheptyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660)[1]. | [Synthesis]
General procedure: preparation of mono-Boc-protected 1,7-diaminoheptane. Di-tert-butyl dicarbonate (Boc2O, 0.500 g, 2.291 mmol) was dissolved in chloroform (CHCl3, 10 mL) and the solution was added slowly and dropwise to a solution of 1,7-diaminoheptane (11.45 mmol) in chloroform (50 mL). The reaction mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated and purified by fast column chromatography (silica gel, SiO2) using a gradient elution (0-10% MeOH) with chloroform/methanol (MeOH) containing 1% triethylamine (Et3N) to afford mono-Boc-protected 1,7-diaminoheptane ((tert-butyl (7-aminoheptyl)carbamate) as a colorless semi-solid (0.473 g, 90% yield ).1H NMR (CDCl3) δ: 4.52 (broad single peak, 1H), 3.12 (quadruple peak, J = 6.2 Hz, 2H), 2.70 (triple peak, J = 6.8 Hz, 2H), 1.43-1.23 (multiple peaks, 19H). | [References]
[1] Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1. |
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