1000403-03-1
中文名稱
INT767
英文名稱
INT-767
CAS
1000403-03-1
分子式
C25H45NaO6S
分子量
496.68
MOL 文件
1000403-03-1.mol
更新日期
2026/07/20 15:11:35
1000403-03-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 205.5 mg/mL (415.44 mM)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist potentially for the treatment of hepatic fibrosis. INT-767 significantly improved serum liver enzymes, hepatic inflammation, and biliary fibrosis in Mdr2(-/-) mice. INT-767 significantly induced bile flow and biliary HCO?3- output, as well as gene expression of carbonic anhydrase 14, an important enzyme able to enhance HCO?3- transport, in an Fxr-dependent manner. In addition, INT-767 dramatically reduced bile acid synthesis via the induction of ileal Fgf15 and hepatic Shp gene expression, thus resulting in significantly reduced biliary bile acid output in Mdr2(-/-) mice.