1000802-52-7
1000802-52-7 結(jié)構(gòu)式
基本信息
1-(2-(pyrrolidin-1-yl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-di...
1-[2-(pyrrolidin-1-yl)ethyl]-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-[2-(1-Pyrrolidinyl)ethyl]-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-(2-(pyrrolidin-1-yl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1H-Pyrazole, 1-[2-(1-pyrrolidinyl)ethyl]-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
物理化學(xué)性質(zhì)
制備方法
269410-08-4
7250-67-1
1000802-52-7
以4-吡唑硼酸頻哪醇酯（1.7g，8.8mmol）和N-(2-氯乙基)吡咯烷鹽酸鹽（1.48g，8.70mmol）為原料，在碳酸鉀（3.7g，27.00mmol）存在下，于DMF（15mL）中80℃攪拌反應(yīng)6小時(shí)。反應(yīng)完成后，將反應(yīng)混合物用水（50mL）稀釋，并用二氯甲烷（50mL×3）萃取。合并有機(jī)層，用飽和氯化鈉水溶液（15mL）洗滌，無(wú)水硫酸鈉干燥，減壓濃縮。通過(guò)硅膠柱色譜法純化殘余物，以二氯甲烷/乙酸乙酯（v/v，20/1）為洗脫劑，得到淺黃色液體產(chǎn)物1-[2-(1-吡咯烷)乙基]-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑（1.27g，收率50.10%）。質(zhì)譜（ESI，正離子模式）m/z：292.10 [M + 1]+。
參考文獻(xiàn)：
[1] Patent: WO2016/615, 2016, A1. Location in patent: Paragraph 00719
[2] Patent: US2010/273796, 2010, A1. Location in patent: Page/Page column 20-21
[3] Patent: US2011/34474, 2011, A1. Location in patent: Page/Page column 22
[4] Patent: US2011/71153, 2011, A1. Location in patent: Page/Page column 21
[5] Patent: US2011/92498, 2011, A1. Location in patent: Page/Page column 20-21