1000817-20-8
中文名稱
化合物 T28173
英文名稱
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester
CAS
1000817-20-8
分子式
C26H25N3O4S2
分子量
507.62
MOL 文件
1000817-20-8.mol
1000817-20-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28173 英文別名
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester物理化學(xué)性質(zhì)
沸點(diǎn)671.1±55.0 °C(Predicted)
密度1.316±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.91±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
NIK-250 is a P-glycoprotein inhibitor. NIK250 might be useful in reversing MDR, which often develops during chemotherapy of advanced or hormone-resistant prostatic cancer. NIK250 could also reverse multidrug resistance in human glioma cells. The glioma cell lines were the two MRP-expressing cell lines, T98G and IN500, an MDR1-expressing cell line, CCF-STTG1, and the MRP1 MDR1-non-expressing cell line, IN157.