100217-92-3
英文名稱
[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone
CAS
100217-92-3
分子式
C30H40O8
分子量
528.634
MOL 文件
100217-92-3.mol
100217-92-3 結(jié)構(gòu)式
基本信息
英文別名
NSC368674NSC-368674
NSC 368674
Physapubenolide
(+)-Physapubenolide
[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone
應(yīng)用領(lǐng)域
用途一
Physapubenolide is natural cytotoxic withanolide antitumor agent, inducing apoptosis by decreasing mitochondrial membrane potential and elevating the Bax/Bcl-2 protein expression ratio. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway.