101189-47-3
中文名稱
101189-47-3
英文名稱
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
CAS
101189-47-3
分子式
C13H20N6S
分子量
292.4
MOL 文件
101189-47-3.mol
101189-47-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15005 英文別名
CP-66,9482-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-
1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
物理化學(xué)性質(zhì)
沸點517.0±42.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.38±0.10(Predicted)
常見問題列表
生物活性
CP-66948 是 histamine H2 受體拮抗劑，能夠抑制胃酸分泌，保護粘膜的作用。體內(nèi)研究
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED 50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED 50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED 50 values of 12 mg/kg per os and 6 mg/kg subcutaneously).