101387-97-7
中文名稱(chēng)
101387-97-7
英文名稱(chēng)
5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
CAS
101387-97-7
分子式
C22H25N3O2S
分子量
395.52
MOL 文件
101387-97-7.mol
101387-97-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T19549 英文別名
Ro-18-53625,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
Indeno[5,6-d]imidazol-6(1H)-one, 5,7-dihydro-2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-5,5,7,7-tetramethyl-
物理化學(xué)性質(zhì)
沸點(diǎn)593.4±60.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)10.28±0.60(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Ro18-5362 是一種活性較低的 Ro 18-5364 前體。即使在濃度高達(dá) 0.1 mM 下，Ro 18-5362 也不能顯著影響 H++K+-ATPase 活性。體外研究
Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H + +K + )-ATPase activity and associated proton translocation. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H + +K + )-ATPase, decreasing enzymatic activity with an apparent K i of 0.1 μM.