1021950-79-7
中文名稱(chēng)
金蓮花堿
英文名稱(chēng)
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
CAS
1021950-79-7
分子式
C12H13NO3
分子量
219.24
MOL 文件
1021950-79-7.mol
1021950-79-7 結(jié)構(gòu)式
基本信息
中文別名
馬齒莧酰胺E 英文別名
TrollineOleracein E
Trolline（(±)-Trolline）
Trolline((±)-Trolline)
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-
應(yīng)用領(lǐng)域
用途一
Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation.