102271-49-8
中文名稱
102271-49-8
英文名稱
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
CAS
102271-49-8
分子式
C19H26O3
分子量
302.41
MOL 文件
102271-49-8.mol
更新日期
2023/03/20 15:41:23
102271-49-8 結(jié)構(gòu)式
基本信息
中文別名
化合物PGS-IN-1 英文別名
PGS-IN-1α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- (9CI)
物理化學(xué)性質(zhì)
沸點(diǎn)429.1±45.0 °C(Predicted)
密度1.096±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.51±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
102271-49-8價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-101587 | 102271-49-8 PGS-IN-1 | 102271-49-8 | 1mg | 500元 |
| 2026/06/05 | HY-101587 | 102271-49-8 PGS-IN-1 | 102271-49-8 | 5mg | 800元 |
| 2026/06/05 | HY-101587 | 102271-49-8 (E)-KME-4 | 102271-49-8 | 10 mM * 1 mLin DMSO | 880元 |
常見(jiàn)問(wèn)題列表
生物活性
PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制劑，IC50 值為0.28 μM；也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性，IC50 值為 1.05 μM。靶點(diǎn)
|
5-Lipoxygenase 1.05 μM (IC 50 ) |
體外研究
The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans ). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC 50 =0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC 50 =1.05 μM).