1026075-53-5
中文名稱
噻嗎咯爾雜質(zhì)E
英文名稱
TiMolol IMpurity E
CAS
1026075-53-5
分子式
C17H26N4O6S
分子量
414.48
MOL 文件
1026075-53-5.mol
更新日期
2025/01/14 16:10:34
1026075-53-5 結(jié)構(gòu)式
基本信息
中文別名
噻嗎洛爾雜質(zhì)E噻嗎咯爾雜質(zhì)E
噻嗎洛爾馬來酸酯
噻嗎洛爾EP雜質(zhì)E
蒂莫洛爾EP雜質(zhì)E
馬來酸噻嗎洛爾雜質(zhì)E
馬來酸噻嗎洛爾EP雜質(zhì)E
噻嗎洛爾相關(guān)化合物E(USP)
噻嗎洛爾雜質(zhì)E (EP/BP)
英文別名
TiMolol IMpurity ETimolol EP Impurity E
Timolol Maleate EP Impurity E
Timolol EP Impurity E/ Timolol Related Compound E
(S)-3-(tert-Butylamino)-1-(4-morpholino-1,2,5-thiadiazol-3-yloxy)propan-2-yl hydrogen maleate
(Z)-4-[(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-yl]oxy-4-oxobut-2-enoic acid
(2Z)-4-[(1S)-1-[[(1,1-Dimethylethyl)amino]methyl]-2-[[4-(morpholin-4-yl)-1,2,5- thiadiazol-3-yl]oxy]ethoxy]-4-oxobut-2-enoic Acid
2-Butenedioic acid (2Z)-, 1-[(1S)-1-[[(1,1-dimethylethyl)amino]methyl]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]ethyl] ester
1-?[(1S)?-?1-?[[(1,?1-?Dimethylethyl)?amino]?methyl]?-?2-?[[4-?(4-?morpholinyl)?-?1,?2,?5-?thiadiazol-?3-?yl]?oxy]?ethyl] Ester (2Z)?-?2-?Butenedioic Acid DISCONTINUED
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
沸點618.1±55.0 °C(Predicted)
密度1.300±0.06 g/cm3(Predicted)
儲存條件2-8°C
酸度系數(shù)(pKa)2.31±0.25(Predicted)
外觀White to off-white Solid
主要應(yīng)用pharmaceutical (small molecule)
InChI1S/C17H26N4O6S/c1-17(2,3)18-10-12(27-14(24)5-4-13(22)23)11-26-16-15(19-28-20-16)21-6-8-25-9-7-21/h4-5,12,18H,6-11H2,1-3H3,(H,22,23)/b5-4-/t12-/m0/s1
InChIKeyMGIAXRFZDNBKRF-RXNFCKPNSA-N
SMILES[s]1nc(c(n1)OC[C@@H](OC(=O)\C=C/C(=O)O)CNC(C)(C)C)N2CCOCC2
安全數(shù)據(jù)
應(yīng)用領(lǐng)域
用途一
1-?[(1S)?-?1-?[[(1,?1-?Dimethylethyl)?amino]?methyl]?-?2-?[[4-?(4-?morpholinyl)?-?1,?2,?5-?thiadiazol-?3-?yl]?oxy]?ethyl] Ester (2Z)?-?2-?Butenedioic Acid (Timolol EP Impurity E; Timolol BP Impurity E; Timolol USP Related Compound E) is an impurity of Timolol (T4437005), an adrenergic blocking agent (1); antiarrhythmic (class II); antianginal; antiglaucoma (2) and antihypertensive (3) agent.