102636-74-8
102636-74-8 結(jié)構(gòu)式
基本信息
化合物 T14969
Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI)
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-110249 | CINPA1 | 102636-74-8 | 1 mg | 304元 |
| 2025/12/22 | HY-110249 | CINPA1 CINPA1 | 102636-74-8 | 5mg | 1200元 |
| 2025/12/22 | HY-110249 | CINPA1 CINPA1 | 102636-74-8 | 10mM * 1mLin DMSO | 1320元 |
常見問題列表
IC50: ~70 nM (CAR)
CINPA1 (1μM ; 24 hours) inhibits CAR-mediated transactivation without activating PXR in HepG2 cells.
CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM.
CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed.
CINPA1 does not alter the protein levels or subcellular localization of CAR.
CINPA1 increases corepressor and reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays.
CINPA1 disrupts CAR binding to the promoter regions of target genes in chromatin immunoprecipitation assays.
CINPA1 efficiently inhibits CAR-LBD interaction with the coactivator peptide that suggesting that CINPA1 is a ligand of CAR.