1032265-67-0

中文名稱 SIM 010603; SIM-010603

英文名稱 SIM010603

CAS 1032265-67-0

分子式 C22H25FN4O2

分子量 396.46

MOL 文件 1032265-67-0.mol

1032265-67-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物 SIM010603

英文別名

SIM010603
SIM 010603
SIM-010603

物理化學(xué)性質(zhì)

沸點(diǎn)602.7±55.0 °C(Predicted)

密度1.294±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)11.68±0.20(Predicted)

應(yīng)用領(lǐng)域

用途一

SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.

常見(jiàn)問(wèn)題列表

概述

Tafetinib analogue 1是酪氨酸激酶受體抑制劑Tafetinib (SIM010603)的類似物。