1032265-67-0
中文名稱
SIM 010603; SIM-010603
英文名稱
SIM010603
CAS
1032265-67-0
分子式
C22H25FN4O2
分子量
396.46
MOL 文件
1032265-67-0.mol
1032265-67-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點602.7±55.0 °C(Predicted)
密度1.294±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.68±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.