103404-90-6

中文名稱 2-羥基-D-谷氨酸

英文名稱 D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT

CAS 103404-90-6

分子式 C5H9NaO5

分子量 172.11

MOL 文件 103404-90-6.mol

更新日期 2026/04/17 10:40:56

103404-90-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 2-羥基-D-谷氨酸價格(試劑級) 常見問題列表

基本信息

中文別名

2-羥基-D-谷氨酸
D-A-羥基戊二酸二鈉
2-羥基-D-谷氨酸鈉
D-Α-羥基戊二酸二鈉鹽
(R)-2-羥基戊二酸鈉
D-2-羥基戊二酸二鈉鹽
(R)-2-羥基戊二酸二鈉鹽
2-羥基-D-谷氨酸二鈉鹽
(R)-2-羥基戊二酸二鈉鹽, D-A-羥基戊二酸二鈉
D-2-HYDROXYPENTANEDIOIC ACID鈥NA+

英文別名

sodiuM 2-hydroxypentanedioate
(r)-2-hydroxypentanedioic acid
Disodium (R)-2-hydroxyglutarate
(2R)-2-Hydroxypentanedioic acid
D-A-HYDROXYGLUTARIC ACID DISODIUM
SodiuM (R)-2-hydroxypentanedioate
D-α-Hydroxyglutaric acid disodium
isodium,(2R)-2-hydroxypentanedioate
D-ALPHA-HYDROXYGLUTARIC ACID DISODIU
disodium:(2R)-2-hydroxypentanedioate

所屬類別

生物化工：谷氨酸類衍生物

物理化學(xué)性質(zhì)

熔點(diǎn)>291°C (dec.)

儲存條件-20°C

溶解度PBS (pH 7.2): 10 mg/ml

形態(tài)結(jié)晶固體

顏色White to light yellow

旋光度 (Optical Rotation)[α]/D 8.5±1.5°, c = 1 in NaOH

水溶解性溶于水至100mM

BRN5318041

穩(wěn)定性吸濕性

主要應(yīng)用cell analysis
peptide synthesis

InChIInChI=1/C5H8O5.Na.H/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/t3-;;/s3

InChIKeyDZHFTEDSQFPDPP-HWYNEVGZSA-L

SMILES[C@H](O)(C(=O)O)CCC(=O)O.[NaH] |&1:0,r|

安全數(shù)據(jù)

WGK Germany3

海關(guān)編碼29181990

存儲類別11 - Combustible Solids

圖譜信息

2-羥基-D-谷氨酸(103404-90-6)質(zhì)譜(MS)
2-羥基-D-谷氨酸(103404-90-6)核磁圖(¹HNMR)

2-羥基-D-谷氨酸價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-100542R	2-羥基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium (Standard)	103404-90-6	5 mg	658元
2026/06/05	HY-100542R	2-羥基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium (Standard)	103404-90-6	10 mg	987元
2026/06/05	HY-100542R	2-羥基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium (Standard)	103404-90-6	25 mg	1777元

常見問題列表

生物活性

Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一種競爭性α-ketoglutarate-dependent dioxygenases抑制劑，其 Ki值為10.87 ± 1.85 mM。

靶點(diǎn)

Target	Value
α-ketoglutarate-dependent dioxygenase

體外研究

在U-87MG細(xì)胞中，(R)-2-Hydroxyglutarate作為α-KG的弱拮抗劑抑制α-KG依賴性組蛋白脫甲基化酶，并增加H3K9和H3K79的二甲基化作用。此外，(R)-2-Hydroxyglutarate抑制ATP合酶與mTOR信號，因此引起生長阻滯和腫瘤細(xì)胞殺傷。

體內(nèi)研究

D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO ₂ production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.