104195-17-7
104195-17-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28741 英文別名
SDZ NVI-085naphtoxazine
[4aR,(-)]-3,4,4aβ,5,10,10aα-Hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine
物理化學(xué)性質(zhì)
沸點(diǎn)417.6±45.0 °C(Predicted)
密度1.19±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)7.45±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
SDZ-NVI-085, also known as Naphtoxazine, is an α1 adrenergic receptor agonist potentially for the treatment of cognitive disorders and major depressive disorder. SDZ-NVI-085 behaves as a competitive antagonist of 5-hydroxytryptamine. SDZ-NVI-085 shifted 5-HT concentration-effect curves to the right, in a concentration-dependent manner, and Schild regression gave a pA2 estimate of 8.0.