104557-24-6
中文名稱
脫乙酰頭孢匹林鈉鹽
英文名稱
Desacetyl Cephapirin SodiuM Salt
CAS
104557-24-6
分子式
C15H16N3NaO5S2
分子量
405.42
MOL 文件
104557-24-6.mol
104557-24-6 結(jié)構(gòu)式
基本信息
中文別名
脫乙酰頭孢匹林鈉鹽DESACETYL CEPHAPIRIN SODIUM SALT[干冰運(yùn)輸]
(6R-反式)-3-(羥基甲基)-8-氧代-7-[[(4-吡啶基硫基)乙?；鵠氨基]-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-2-羧酸單鈉鹽
英文別名
Desacetylcephapirin sodiumDeacetylcephapirin SodiuM Salt
Desacetyl Cephapirin SodiuM Salt
(6R,7R)-3-(HydroxyMethyl)-8-oxo-7-[[2-(4-pyridinylthio)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt
(6R-trans)-3-(HydroxyMethyl)-8-oxo-7-[[(4-pyridinylthio)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt
(6R-trans)-3-(Hydroxymethyl)-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
物理化學(xué)性質(zhì)
熔點(diǎn)>160°C (dec.)
儲(chǔ)存條件-20°C Freezer, Under Inert Atmosphere
溶解度可溶于DMSO（輕微）、甲醇（輕微、加熱）、水（輕微、加熱）
形態(tài)固體
顏色淡黃色至棕色
穩(wěn)定性吸濕性
常見(jiàn)問(wèn)題列表
生物活性
Desacetylcephapirin sodium (Deacetylcephapirin sodium) 是 Cephapirin (HY-A0153A) 的一種活性代謝物。Desacetylcephapirin sodium 對(duì)金黃色葡萄球菌和凝固酶陰性葡萄球菌乳腺炎病原體有抗菌作用。靶點(diǎn)
antibacterial
體外研究
Desacetylcephapirin sodium exhibits inhibitory activity on
Streptococcus dysgalactiae
, with MIC
50
s both of 0.25 μg/mL for clinical and subclinical bacterial strain.
Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC
50
s both of 0.12 μg/mL for clinical and subclinical bacterial strain.