104756-72-1
中文名稱
二甲基 4-(3,4-二甲氧苯基)-1-羥基-5,6,7-三甲氧基萘-2,3-二甲酸基酯
英文名稱
TA 7552
CAS
104756-72-1
分子式
C25H26O10
分子量
486.47
MOL 文件
104756-72-1.mol
104756-72-1 結(jié)構(gòu)式
基本信息
中文別名
二甲基 4-(3,4-二甲氧苯基)-1-羥基-5,6,7-三甲氧基萘-2,3-二甲酸基酯 英文別名
TA 75524-(3,4-DIMETHOXY-PHENYL)-1-HYDROXY-5,6,7-TRIMETHOXY-NAPHTHALENE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
2,3-Naphthalenedicarboxylic acid, 4-(3,4-dimethoxyphenyl)-1-hydroxy-5,6,7-trimethoxy-, 2,3-dimethyl ester
常見(jiàn)問(wèn)題列表
生物活性
TA-7552 是一種有效的膽固醇降低劑。體內(nèi)研究
TA-7552 is a potent cholesterol-lowering agent. When TA-7552 is mixed with unsupplemented CLEA CE-2 powder in a concentration of 0.05% and administered to rats for 7 days, TA-7552 does not reduce the normal level of serum cholesterol. The hypocholesterolemic effect of TA-7552 is apparent at the lowest concentration (0.01%) of the drug in the diet, corresponding to a daily dose of ~10 mg/kg body weight, and maximal at the highest concentration of 0.2% TA-7552, lowering serum total cholesterol by 72% while elevating serum HDL cholesterol by 88%. TA-7552 also dose dependently suppresses this rise of hepatic cholesterol, and its lowering rate at the maximal dose is 90%.