105118-14-7
105118-14-7 結(jié)構(gòu)式
基本信息
DATELLIPTIUM CHLORIDE鹽酸鹽
2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑,氯化物(1:1)
物理化學(xué)性質(zhì)
H2O:41.67(Max Conc. mg/mL);104.71(Max Conc. mM)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-U00337 | 2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 Datelliptium chloride | 105118-14-7 | 5 mg | 1500元 |
| 2026/06/05 | HY-U00337 | 2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 Datelliptium chloride | 105118-14-7 | 10 mM * 1 mL in Water | 1650元 |
| 2026/06/05 | HY-U00337 | 2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 Datelliptium chloride | 105118-14-7 | 10 mg | 2100元 |
常見問題列表
Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.