105737-62-0

中文名稱 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE

英文名稱 CGP 20712 A

CAS 105737-62-0

分子式 C24H29F3N4O8S

分子量 590.57

MOL 文件 105737-62-0.mol

105737-62-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) CGP 20712 A 價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物 T10778
化合物 CGP 20712 A
CGP 20712A MONOMETHANESULFONATE

英文別名

CGP207122HCl
CGP 20712 mesylate
CGP 20712 DIHYDROCHLORIDE
CGP-20712A methanesulfonate salt
CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE
CGP-20712A methanesulfonate salt solid, >=98% (HPLC)
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate

物理化學(xué)性質(zhì)

儲(chǔ)存條件2-8°C

溶解度H₂O: 10 mg/mL

形態(tài)solid

顏色white

水溶解性H2O: >10mg/mL
DMSO: 100mg/mL

InChIKeyVFPOVCXWKBYDNF-UHFFFAOYSA-N

SMILESCS(O)(=O)=O.Cn1cc(nc1-c2ccc(OCC(O)CNCCOc3ccc(O)c(c3)C(N)=O)cc2)C(F)(F)F

安全數(shù)據(jù)

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

CGP 20712 A 價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-101355B	CGP 20712 A CGP 20712 A	105737-62-0	1 mg	1800元
2026/06/05	HY-101355B	CGP 20712 A CGP 20712 A	105737-62-0	5 mg	4500元
2025/12/22	HY-101355A	CGP 20712 A CGP 20712 dihydrochloride	105737-62-0	1 mg	1735元

常見問題列表

生物活性

CGP 20712 A (CGP 20712 mesylate) 是一種高選擇性 β1-adrenoceptor 拮抗劑，IC50 為 0.7 nM，是對(duì) β2 腎上腺素受體的選擇性約為 10,000 倍。

靶點(diǎn)

IC50: 0.7 nM (β1-adrenoceptor)

體外研究

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

體內(nèi)研究