1058722-45-4
中文名稱
(2Z)-2-氰基-3,4-二羥基-N-[4-(三氟甲基)苯基]-2-丁烯酰胺
英文名稱
4-Hydroxy-TeriflunoMide
CAS
1058722-45-4
分子式
C12H9F3N2O3
分子量
286.21
MOL 文件
1058722-45-4.mol
1058722-45-4 結(jié)構(gòu)式
基本信息
中文別名
(2Z)-2-氰基-3,4-二羥基-N-[4-(三氟甲基)苯基]-2-丁烯酰胺 英文別名
Teriflunomide 4-Hydroxy4-Hydroxy-TeriflunoMide
Teriflunomide Impurity 8
WHYQOFDUXDGMTM-KTKRTIGZSA-N
(Z)-2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
2-Butenamide, 2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
所屬類別
有機(jī)原料：酰胺類化合物物理化學(xué)性質(zhì)
InChIInChI=1S/C12H9F3N2O3/c13-12(14,15)7-1-3-8(4-2-7)17-11(20)9(5-16)10(19)6-18/h1-4,18-19H,6H2,(H,17,20)/b10-9-
InChIKeyWHYQOFDUXDGMTM-KTKRTIGZSA-N
SMILESC(NC1=CC=C(C(F)(F)F)C=C1)(=O)/C(/C#N)=C(\O)/CO
應(yīng)用領(lǐng)域
用途一
4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.