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105963-46-0

中文名稱 105963-46-0
英文名稱 TOK 8801
CAS 105963-46-0
分子式 C17H21N3OS
分子量 315.439
MOL 文件 105963-46-0.mol
105963-46-0 結(jié)構(gòu)式 105963-46-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13180
英文別名
TOK 8801
Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-

物理化學(xué)性質(zhì)

密度1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.27±0.40(Predicted)

常見問題列表

生物活性
TOK-8801 是一種合成的二氫咪唑并噻唑羧酰胺,正在開發(fā)作為免疫調(diào)節(jié)劑。
體外研究

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator. TOK-8801 augments the in vitro anti-SRBC PFC response of murine splenocytes in a bell-shaped manner. The stimulatory effect of TOK-8801 is observed at concentrations of 2.5×10 -7 to 2.5×10 -5 M and is diminished at 10 -4 M. The cell-viability is not altered during the culture with TOK-8801 at any doses used in this experiment (10 -7 to 10 -4 M). TOK-8801 enhances the 3 H-TdR uptake of these responses in a bell-shaped manner, and effective concentrations of TOK-8801 are 10 -7 to 10 -5 M.

體內(nèi)研究

The anti-SRBC PFC response per spleen, which is prominently lowered by restraint-stress (P<0.05), is significantly restored by the administration of TOK-8801 (0.5 mg/kg, P<0.05). The number of total splenic lymphocytes in restraint-stress is decreased, but there are no significant changes in the number of total splenic lymphocytes by the treatment with TOK-8801. When TOK-8801 is administered orally at doses of 0.1 to 10 mg/kg, the number of plaque forming cell (PFC) significantly decreases or tends to decrease. Treatment of TOK-8801 at doses of 0.1 to 1 mg/kg causes significant suppression in the delayed-type hypersensitivity (DTH) reaction induced in high responder.

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