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107015-83-8

中文名稱 淀粉-Β-蛋白片段12-28
英文名稱 H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS 107015-83-8
分子式 C89H135N25O25
分子量 1955.18
MOL 文件 107015-83-8.mol
更新日期 2026/07/10 13:21:03
107015-83-8 結(jié)構(gòu)式 107015-83-8 結(jié)構(gòu)式

基本信息

中文別名
淀粉-Β-蛋白片段12-28
英文別名
SP17
VHHQKLVFFAEDVGSNK
β-Amyloid (12-28)
BETA-AMYLOID (12-28)
AMyloid b-Protein (12-28)
AMYLOID BETA-PROTEIN (12-28)
M.W. 1955.20 C89H135N25O25
AMYLOID, BETA- (12-28), HUMAN
Amyloidb-Peptide(12-28)(human)
AMYLOID B-PROTEIN FRAGMENT 12-28
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

儲(chǔ)存條件−20°C
溶解度≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O
形態(tài)固體
水溶解性Soluble to 0.70 mg/ml in water
序列H-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

應(yīng)用領(lǐng)域

參考質(zhì)量標(biāo)準(zhǔn)
外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%

安全數(shù)據(jù)

WGK Germany3
淀粉-Β-蛋白片段12-28價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-81mg800元
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-85mg2400元
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-810mg3800元

常見問題列表

生物活性
β-amyloid (12-28) 是 β-淀粉樣蛋白 (β1-42) 的肽片段。 β1-42 是 42 個(gè)氨基酸的蛋白質(zhì),是老年斑核心的主要成分。β-amyloid (12-28) 具有聚集特性。β-amyloid (12-28) 有潛力用于阿爾茨海默氏病的研究。
靶點(diǎn)

Amyloid-β

體外研究

β-amyloid (12-28) may exert dysregulation cognitive effects by means of defective coordination of potassium channel function in nerve, glia and endothelial cells.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

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