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107334-06-5

中文名稱 化合物 T28333
英文名稱 PD 138312
CAS 107334-06-5
分子式 C19H23FN4O3
分子量 374.41
MOL 文件 107334-06-5.mol
107334-06-5 結(jié)構(gòu)式 107334-06-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T28333
英文別名
PD 138312
7-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

物理化學(xué)性質(zhì)

沸點(diǎn)591.5±50.0 °C(Predicted)
密度1.442±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)6.03±0.70(Predicted)

應(yīng)用領(lǐng)域

用途一
PD 138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally.
"107334-06-5" 相關(guān)產(chǎn)品信息
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