107431-28-7
中文名稱(chēng)
化合物 ENADOLINE (FREE BASE)
英文名稱(chēng)
enadoline
CAS
107431-28-7
分子式
C24H32N2O3
分子量
396.522
MOL 文件
107431-28-7.mol
107431-28-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 ENADOLINE (FREE BASE) 英文別名
Cam 569Pd 129289
N-Methyl-N-(7-(1-pyrolidinyl)-1-oxaspiro(4,5)dec-8-yl)-4-benzofuranacetamide
4-Benzofuranacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-
應(yīng)用領(lǐng)域
用途一
Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.