1079821-35-4
1079821-35-4 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
NCG21 is a GPR120 agonist. NCG21 showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that express GPR120 endogenously. Moreover, administration of NCG21 into the mouse colon caused an increase in plasma GLP-1 levels.常見問題列表
概述
GPR120 Agonist 5 (compound 12) 是一種以 GPR120 為靶點(diǎn)的激動(dòng)劑 (EC50=1.2 μM)。GPR120 Agonist 5 通過與 GPR120 受體結(jié)合，促進(jìn)類胰高血糖素-1 (GLP-1) 的釋放，GLP-1 進(jìn)而與其在胰腺 β 細(xì)胞上的受體結(jié)合，增加胰島素的分泌，從而降低血糖水平。GPR120 Agonist 5 還有助于減輕慢性低度炎癥，這在肥胖、胰島素抵抗和 2 型糖尿病的發(fā)病機(jī)制中起著重要作用。GPR120 Agonist 5 可用于對(duì) GPR120 在代謝和炎癥疾病中作用機(jī)制的研究。