1080623-12-6
中文名稱
化合物 T24951
英文名稱
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-
CAS
1080623-12-6
分子式
C18H20ClN5S
分子量
373.9
MOL 文件
1080623-12-6.mol
1080623-12-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T24951 英文別名
VUF10497VUF-10497
VUF 10497
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-
物理化學(xué)性質(zhì)
熔點(diǎn)153.8-155.7 °C
沸點(diǎn)563.5±60.0 °C(Predicted)
密度1.360±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9.08±0.59(Predicted)
應(yīng)用領(lǐng)域
用途一
VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 also possesses considerable affinity for the human histamine H(1) receptor (H(1)R) and therefore represent a novel class of dual action H(1)R/H(4)R ligands, a profile that potentially leads to added therapeutic benefit. VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat.