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108433-95-0

中文名稱 MAGAININ 2抗菌肽
英文名稱 MAGAININ II
CAS 108433-95-0
分子式 C114H180N30O29S
分子量 2466.9
MOL 文件 108433-95-0.mol
更新日期 2026/06/08 20:11:22
108433-95-0 結(jié)構(gòu)式 108433-95-0 結(jié)構(gòu)式

基本信息

中文別名
蛙皮素II
GS-23
蛙皮素 2
馬蓋寧 II
定制肽/23肽
MAGAININ 2肽
MAGAININ 2抗菌肽
英文別名
MAGAININ 2
Aids007842
MAGAININ II
Aids-007842
Magainin II peptide
MAGAININ II USP/EP/BP
GIGKFLHSAKKFGKAFVGEIMNS
Magainin II, ≥97% (HPLC)
Magainin 2 (Xenopus laevis)
Magainin 2 peptide, Xenopus
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)2444.0±65.0 °C(Predicted)
密度1.275±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
序列H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH
InChIKeyMGIUUAHJVPPFEV-VCVGOEFZNA-N

應(yīng)用領(lǐng)域

多肽
蛙皮素2(Magainin II)是一種具有抗菌效果的多肽,由23個(gè)氨基酸組成。研究證明Magainin II具有較強(qiáng)的殺菌效果,主要是通過誘導(dǎo)大腸桿菌的早期凋亡從而引起其形態(tài)學(xué)改變,進(jìn)而促發(fā)殺菌效果。蛙皮素2通過滲透細(xì)胞膜來殺死細(xì)菌,主要作用機(jī)理是引起細(xì)胞的滲透性腫脹和隨后的細(xì)胞破裂,擾亂負(fù)責(zé)滲透平衡的膜功能,導(dǎo)致細(xì)胞消亡,而Magainin II對哺乳動(dòng)物細(xì)胞沒有明顯的毒性。
參考質(zhì)量標(biāo)準(zhǔn)
外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
存儲類別11 - Combustible Solids
蛙皮素2價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2026/06/05HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-0500μg900元
2026/06/05HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-01mg1600元
2026/06/05HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-05mg3400元

常見問題列表

生物活性
Magainin 2 (Magainin II) 是一種抗菌肽 (AMP),從非洲爪蟾皮膚中分離得到。Magainin 2 顯示抗生素活性對許多革蘭氏陰性和革蘭氏陽性細(xì)菌。Magainin 2 對原生動(dòng)物也有活性。Magainin 2 通過優(yōu)先與細(xì)菌膜中豐富的陰離子磷脂相互作用而發(fā)揮細(xì)胞毒性作用。
體外研究

Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei.

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