109229-22-3
109229-22-3 結構式
基本信息
6-芐基-5,6,7,8-四氫吡啶并[4,3-D]嘧啶-4(3H)-酮
6-芐基-5,6,7,8-四氫吡啶并[4,3-D]嘧啶-4(3H)-酮 6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE
3-d]pyriMidin-4(3H)-one
6-benzyl-3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidin-4-one
6-benzyl-1H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-one
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)
Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-4(3H)-one
6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one
6-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
6-(phenylmethyl)-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one
物理化學性質(zhì)
制備方法
3473-63-0
1454-53-1
109229-22-3
1. 在350 mL密封反應釜中，將1-芐基-4-氧代哌啶-3-羧酸乙酯鹽酸鹽（50.0 g，0.168 mol）、醋酸甲脒（16.2 g，0.201 mol）、4.37 M甲醇鈉的甲醇溶液（190 mL）及甲醇（200 mL）混合。2. 將反應混合物加熱至85℃，維持16小時。3. 反應完成后，冷卻混合物并減壓濃縮。4. 將濃縮殘余物溶解于1 N NaOH溶液（150 mL）中，隨后倒入冰水中。5. 緩慢加入冰醋酸調(diào)節(jié)混合物pH至7，析出棕褐色固體。6. 過濾收集固體，依次用水和冷乙醚洗滌。7. 高真空干燥后，得到6-芐基-5,6,7,8-四氫吡啶并[4,3-d]嘧啶-4(3H)-酮，為褐色固體（26.2 g，收率61.4%）。8. 質(zhì)譜分析顯示[M + H]+ = 242.2。9. 1H NMR (DMSO-d6) δ: 2.29 (t, J = 5.8 Hz, 2H), 2.61 (t, J = 5.8 Hz, 2H), 3.26 (s, 2H), 3.64 (s, 2H), 7.21-7.36 (m, 6H), 7.96 (s, 1H)。
參考文獻：
[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 22; 23; 27; 28
[2] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 22
[3] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: WO2011/103715, 2011, A1. Location in patent: Page/Page column 38
[5] Patent: WO2011/106276, 2011, A1. Location in patent: Page/Page column 38
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | XW0210922922302 | 6-芐基-5,6,7,8-四氫吡啶并[4,3-D]嘧啶-4(3H)-酮 | 109229-22-3 | 1G | 187元 |
| 2026/06/05 | XW0210922922301 | 6-芐基-5,6,7,8-四氫吡啶并[4,3-D]嘧啶-4(3H)-酮 | 109229-22-3 | 250MG | 51元 |
| 2025/12/22 | XW0210922922303 | 6-芐基-5,6,7,8-四氫吡啶并[4,3-D]嘧啶-4(3H)-酮 | 109229-22-3 | 5G | 930元 |