109358-46-5
中文名稱
BOC-LEU-ARG-ARG-AMC · 2 HCL
英文名稱
Boc-Leu-Arg-Arg-AMC . 2 HCl
CAS
109358-46-5
分子式
C33H52N10O7
分子量
700.83
MOL 文件
109358-46-5.mol
更新日期
2026/07/07 17:20:43
109358-46-5 結(jié)構(gòu)式
基本信息
英文別名
Boc-LRR-AMCBoc-Leu-Arg-Arg-AMC . 2 HCl
N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-(4-methyl-2-oxochromen-7-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
所屬類別
生物化工：氨基酸物理化學(xué)性質(zhì)
密度1.34±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)11.34±0.46(Predicted)
形態(tài)固體
顏色白色至灰白色
序列Boc-Leu-Arg-Arg-AMC
穩(wěn)定性吸濕性
應(yīng)用領(lǐng)域
用途一
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitatioemission maxima of 340-360/440-460 nm, respectively.