110225-59-7
中文名稱(chēng)
Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-
CAS
110225-59-7
分子式
C22H29NO5
更新日期
2023/03/13 12:41:27
110225-59-7 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Guanfu base I (Acorine) 是 Guanfu base A 的活性代謝產(chǎn)物，是從 Aconitum coreanum 中分離得到的，具有很強(qiáng)的抗心律失常的作用。體內(nèi)研究
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%.