11023-94-2

中文名稱 1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮

英文名稱 Nothofagin

CAS 11023-94-2

分子式 C21H24O10

分子量 436.41

MOL 文件 11023-94-2.mol

11023-94-2 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 圖譜信息 1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮

英文別名

Nothofagin
1-Propanone, 1-(3-β-D-glucopyranosyl-2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-
1-(3-beta-D-Glucopyranosyl-2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone
(1S)-1,5-Anhydro-1-{2,4,6-trihydroxy-3-[3-(4-hydroxyphenyl)propanoyl]phenyl}-D-glucitol

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C

形態(tài)Solid

顏色White to off-white

圖譜信息

1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮(11023-94-2)核磁圖(¹HNMR)

1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-113919	1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮 Nothofagin	11023-94-2	1 mg	5819元
2023/03/20	HY-113919	1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羥基苯基)-3-(4-羥基苯基)-1-丙酮 Nothofagin	11023-94-2	5mg	12500元

常見(jiàn)問(wèn)題列表

生物活性

Nothofagin 是一種二氫查爾酮，是從如意寶 (Aspalathus linearis) 中分離得到的。Nothofagin 通過(guò)阻斷鈣 (calcium) 內(nèi)流來(lái)下調(diào) NF-κB 的轉(zhuǎn)運(yùn)。Nothofagin 具有抗氧化活性，可改善各種炎癥反應(yīng)，例如膿毒癥反應(yīng)和血管炎癥。

體外研究

Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. The production of cytokines are downregulated bynothofagin pre-treatment Nothofagin (TNF-α: 1-10 μM; IL-4: 0.1-10 μM, IL-6: 1-10 μM).
Pre-treatment of DNPHSA-stimulated RBL-2H3 with Nothofagin (10 μM) markedly suppresses the phosphorylation of Lyn, Syk, and Akt.
Nothofagin (30 μM; for 6 hours) results in inhibited formation of LPS-induced (100 ng/mL; 4 hours) paracellular gaps with the formation of dense F-actin rings in HUVECs.
Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo.

體內(nèi)研究

Nothofagin (1 mg/kg; orally; once a day; for 7 days) significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR).