110368-33-7
110368-33-7 結(jié)構(gòu)式
基本信息
中文別名
化合物CH55化合物 T14946
英文別名
CH 554-[(E)-3-(3,5-Di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid
4-[(E)-3-[3,5-Bis(tert-butyl)phenyl]-3-oxo-1-propenyl]benzoic acid
(E)-4-(3-(3,5-Bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)benzoic acid
4-[(E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid
4-[(1E)-3-[3,5-BIS(1,1-DIMETHYLETHYL)PHENYL]-3-OXO-1-PROPENYL]BENZOIC ACID
Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-
Benzoic acid, 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-
物理化學(xué)性質(zhì)
熔點(diǎn)202-203.5 °C
沸點(diǎn)509.5±50.0 °C(Predicted)
密度1.085±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml
酸度系數(shù)(pKa)4.09±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色White to light yellow
穩(wěn)定性感光
CH 55價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-107397 | Ch55 | 110368-33-7 | 1 mg | 545元 |
| 2026/06/05 | HY-107397 | CH 55 Ch55 | 110368-33-7 | 5mg | 1184元 |
| 2026/06/05 | HY-107397 | Ch55 | 110368-33-7 | 10 mM * 1 mLin DMSO | 1302元 |
常見(jiàn)問(wèn)題列表
生物活性
Ch55 是一種有效的合成類維生素 A。Ch55 與 RAR-α 和 RAR-β 受體具有高親和力。Ch55 對(duì)細(xì)胞視黃酸結(jié)合蛋白 (CRABP) 的親和力較低。Ch55 是 HL60 細(xì)胞分化的有效誘導(dǎo)物，EC50 為 200 nM，可用于癌癥的研究。靶點(diǎn)
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RARα
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RARβ
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體外研究
Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC 50 = 0.02 nM) and increasing cholesterol sulfate levels (EC 50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC 50 s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).