113158-34-2

中文名稱(chēng) Norbinaltorphimine Dihydrochloride

英文名稱(chēng) Norbinaltorphimine Dihydrochloride

CAS 113158-34-2

分子式 C40H44ClN3O6

分子量 698.26

MOL 文件 113158-34-2.mol

113158-34-2 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 Norbinaltorphimine Dihydrochloride價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物 T12241

英文別名

(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol

物理化學(xué)性質(zhì)

熔點(diǎn)>280 °C (decomp)

儲(chǔ)存條件Store at RT

溶解度Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO

形態(tài)粉末

顏色Light yellow to gray

InChIKeyJOJPJLHRMGPDPV-LZQROVCBSA-N

SMILESCl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲(chǔ)類(lèi)別11 - Combustible Solids

圖譜信息

Norbinaltorphimine Dihydrochloride(113158-34-2)核磁圖(¹HNMR)

Norbinaltorphimine Dihydrochloride價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-100903	Norbinaltorphimine Dihydrochloride Norbinaltorphimine dihydrochloride	113158-34-2	5 mg	950元
2026/06/05	HY-100903	Norbinaltorphimine Dihydrochloride Norbinaltorphimine dihydrochloride	113158-34-2	10 mg	1500元
2026/06/05	HY-100903	Norbinaltorphimine Dihydrochloride Norbinaltorphimine dihydrochloride	113158-34-2	10 mM * 1 mL in DMSO	1536元

常見(jiàn)問(wèn)題列表

生物活性

Norbinaltorphimine dihydrochloride是一種有效的和選擇性的κ阿片受體 (κ opioid receptor) 拮抗劑。

靶點(diǎn)

κ opioid receptor

體外研究

Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.

體內(nèi)研究

Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.