1146-04-9
中文名稱
隱陡頭菌素M
英文名稱
illudin M
CAS
1146-04-9
分子式
C15H20O3
分子量
248.32
MOL 文件
1146-04-9.mol
更新日期
2025/01/06 12:01:11
1146-04-9 結(jié)構(gòu)式
基本信息
中文別名
隱陡頭菌素M 英文別名
illudin M(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one
(3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)120-122.5° (Matsumoto); mp 128-130° (McMorris)
沸點(diǎn)452.4±45.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
酸度系數(shù)(pKa)12.57±0.70(Predicted)
形態(tài)固體
顏色Off-white to light yellow
InChIInChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1
InChIKeyQVMDIQLUNODCTG-OCCSQVGLSA-N
SMILESC12([C@](O)(C)C(=O)C3C(=C1C)[C@@H](O)C(C)(C)C=3)CC2
常見(jiàn)問(wèn)題列表
生物活性
Illudin M 是一種細(xì)胞毒性真菌倍半萜，可以從 Omphalotus olearius 蘑菇培養(yǎng)基中分離得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗腫瘤活性。體外研究
Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.
Apoptosis Analysis
| Cell Line: | Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) |
| Concentration: | 0.01 μM, 1 μM, 10 μM |
| Incubation Time: | 24 hours, 48 hours,72 hours, 96 hours, 120 hours |
| Result: | Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%). |