1146963-51-0
1146963-51-0 結構式
基本信息
CS-1446
J147-API
J147/J-147
J-147?, >98%
Nootropic J147
J 147(Nootropic Powder)
N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE
(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide
物理化學性質
制備方法
391646-35-8
407-25-0
1146963-51-0
在0℃及氮氣保護下，向攪拌的1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亞甲基]酰肼（500mg，1.97mmol）和三乙胺（0.33mL，2.36mmol）的二氯甲烷（5mL）溶液中緩慢滴加三氟乙酸酐（0.33mL，2.36mmol）。反應混合物在0℃下持續(xù)攪拌1.5小時。反應完成后，將混合物濃縮，殘余物通過柱色譜法使用丙酮/己烷（1:10）作為洗脫劑進行純化，得到目標產物2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亞甲基]酰肼（571mg，收率83%），為淺黃色油狀物。1H NMR（CDCl3）數據如下：δ7.26-7.23（m，4H），7.19（d，J = 8.0Hz，1H），7.12（d，J = 7.5Hz，1H），7.03（d，J = 8.0Hz，1H），6.92（dd，J = 8.5,2.0Hz，1H），3.79（s，3H），2.39（s，3H），2.08（s，3H）。高分辨質譜（ESI-TOF，m/z）分析結果：C18H18N2O2F3（[M + H]+）的計算值為351.1320；實測值為351.1311。
參考文獻：
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 524 - 527
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 5mg | 500元 |
| 2026/06/05 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mM * 1mLin DMSO | 550元 |
| 2026/06/05 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mg | 700元 |
常見問題列表
MAO B; Dopamine transporter
J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC 50 value range of 0.06-0.115 μM) .
J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t
1/2
) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
| Animal Model: | 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls |
| Dosage: | 200 ppm |
| Administration: | The diet was prepared by the addition of 200ppm; 6 months |
| Result: | While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. |