114778-60-8
中文名稱
114778-60-8
英文名稱
9-(3-hydroxypropoxy)guanine
CAS
114778-60-8
分子式
C8H11N5O3
分子量
225.2
MOL 文件
114778-60-8.mol
114778-60-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10615 英文別名
9-(3-hydroxypropoxy)guanine6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-
物理化學(xué)性質(zhì)
密度1.77±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.32±0.20(Predicted)
常見問題列表
生物活性
BRL44385 有效且選擇性地抑制單純皰疹病毒 1 型和 2 型 (HSV-1 和 HSV-2)，水痘帶狀皰疹病毒 (VZV) 和 Epstein-Barr 病毒 (EBV) 復(fù)制。靶點(diǎn)
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HSV-1
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HSV-2
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體內(nèi)研究
BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides high and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavailability of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously.