常見問題列表
生物活性
AhR modulator-1 (compound 6-MCDF) 是一種選擇性的口服活性芳烴受體 (AhR) 調節(jié)劑。AhR modulator-1 部分地通過在腫瘤形成之前抑制前列腺 VEGF 的產(chǎn)生而抑制腫瘤轉移。AhR modulator-1 在大鼠子宮中也具有抗雌激素特性。靶點
Aryl hydrocarbon receptor (AhR)
Prostatic VEGF
Estrogenic
體外研究
AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively.
Cell Proliferation Assay
| Cell Line: | ASPC-1 cells |
| Concentration: | 0.1 μM, 1 μM and 10 μM |
| Incubation Time: | 48 hours, 72 hours, 96 hours |
| Result: | Exhibited dose-dependent growth inhibitory effects. |
體內研究
AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced.
| Animal Model: | C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old) |
| Dosage: | 0 mg/kg, 10 mg/kg, 40 mg/kg |
| Administration: | Oral administration; daily; for 12 weeks |
| Result: | The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced. |