115841-09-3

中文名稱丹酚酸C

英文名稱 Salvianolicacid C

CAS 115841-09-3

分子式 C26H20O10

分子量 492.43

MOL 文件 115841-09-3.mol

更新日期 2026/07/15 17:47:26

115841-09-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域圖譜信息丹酚酸C價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

丹酚酸C
丹參酚酸C
丹酚酸C對照品,
丹酚酸C(標(biāo)準(zhǔn)品)
丹酚酸C(丹參酚酸C)

英文別名

Salvianolicacid C
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid
Benzenepropanoic acid, a-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-,(aR)-
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-
(alphaR)-alpha-[[(2E)-3-[2-(3,4-Dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid

所屬類別

生物化工：提取物

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于丹參。

沸點(diǎn)844.2±65.0 °C(Predicted)

密度1.570

儲(chǔ)存條件Inert atmosphere,2-8°C

溶解度Soluble in methanol and water

酸度系數(shù)(pKa)2.76±0.10(Predicted)

形態(tài)粉末

顏色黃色

InChIKeyGCJWPRRNLSHTRY-QKKCHETFNA-N

SMILESC(O)(=O)[C@H](OC(=O)/C=C/C1=C2C(=C(O)C=C1)OC(C1=CC=C(O)C(O)=C1)=C2)CC1=CC=C(O)C(O)=C1 |&1:3,r|

應(yīng)用領(lǐng)域

用途1

用于含量測定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:具有一定抗氧化、保護(hù)腦組織細(xì)胞損傷、保護(hù)心腦血管系統(tǒng)和抗HIV作用。

用途2

丹酚酸C 1.具有明顯的抗血小板聚集作用。2.自由基清除劑。

圖譜信息

丹酚酸C(115841-09-3)核磁圖(¹HNMR)

丹酚酸C價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/07/06	S0922	丹酚酸C Salvianolic acid C	115841-09-3	1mg	573.13元
2026/07/06	S0922	丹酚酸C Salvianolic acid C	115841-09-3	5mg	1711.71元
2026/06/05	HY-N0319R	丹酚酸C Salvianolic acid C (Standard)	115841-09-3	1 mg	646元

常見問題列表

生物活性

Salvianolic acid C 是細(xì)胞色素 P4502C8 (CYP2C8) 的非競爭性抑制劑和細(xì)胞色素 P4502J2 (CYP2J2) 中等強(qiáng)度的混合抑制劑，其對 CYP2C8 和 CYP2J2 的 Ki 值分別為 4.82 μM 和 5.75 μM。

靶點(diǎn)

CYP2C8

4.82 μM (Ki)

CYP2J2

5.75 μM (Ki)

體外研究

Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K _i s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF?κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells.

體內(nèi)研究

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus.