116457-99-9
中文名稱
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
英文名稱
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS
116457-99-9
分子式
C45H93N2O4PS
分子量
789.27
MOL 文件
116457-99-9.mol
116457-99-9 結(jié)構(gòu)式
基本信息
英文別名
THIOETHERAMIDE PCWLWWVTPUDQTUJU-KDXMTYKHSA-N
Thioetheramide phosphorylcholine
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
常見(jiàn)問(wèn)題列表
概述
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 是一種結(jié)構(gòu)改良的磷脂，可作為分泌性磷脂酶 A2 (sPLA2) 的競(jìng)爭(zhēng)性可逆抑制劑。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 的 IC50 值為 2 μM，底物濃度為 0.5 mM。除了與 sPLA2 的催化位點(diǎn)結(jié)合外，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 還與該酶的激活位點(diǎn)結(jié)合。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 與激活位點(diǎn)的結(jié)合比與催化位點(diǎn)的結(jié)合更緊密。這種雙重相互作用的結(jié)果 是，在低濃度下，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 可能會(huì)激活磷脂酶活性，而不 是抑制它。