一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>116686-15-8

116686-15-8

中文名稱 N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
英文名稱 FK-3311
CAS 116686-15-8
分子式 C15H13F2NO4S
分子量 341.33
MOL 文件 116686-15-8.mol
更新日期 2026/06/03 17:39:17
116686-15-8 結(jié)構(gòu)式 116686-15-8 結(jié)構(gòu)式

基本信息

中文別名
N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
英文別名
FK-3311
CS-1073
FK-3311
FK3311
COX-2 Inhibitor V
COX-2 Inhibitor V, FK3311
N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-
N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide FK3311
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)431.3±55.0 °C(Predicted)
密度1.419±0.06 g/cm3(Predicted)
儲存條件Store at RT
溶解度Soluble in DMSO
酸度系數(shù)(pKa)6.82±0.10(Predicted)
形態(tài)白色固體
顏色Light yellow to yellow
InChI1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
InChIKeyDIIYLGZNZGPXRR-UHFFFAOYSA-N
SMILESFc1c(ccc(c1)F)Oc2c(ccc(c2)C(=O)C)N[S](=O)(=O)C

安全數(shù)據(jù)

WGK GermanyWGK 1
存儲類別11 - Combustible Solids
N-[4-乙?;?2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-14445RN-[4-乙?;?2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
FK 3311 (Standard)
116686-15-85 mg1400元
2026/06/05HY-14445RN-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
FK 3311 (Standard)
116686-15-810 mg2100元
2026/06/05HY-14445RN-[4-乙?;?2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
FK 3311 (Standard)
116686-15-825 mg3780元

常見問題列表

生物活性
FK-3311 (COX-2 Inhibitor V)是選擇性的、細(xì)胞可滲透的、口服 cyclooxygenase-2 (COX-2) 抑制劑,具有抗炎作用。FK-3311 可通過顯著抑制 TxA2 來對肝熱性缺血再灌注損傷起到保護(hù)作用。
靶點(diǎn)
TargetValue
COX-2
()
TxA2
()
體外研究

Cyclooxygenase (COX) is an intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2.
The racemic mixtures and the (R)- and (S)-isomers of the 2 metabolites were inactive in the PGE2 test. IC50 values were more than 100 uM for (2 and 5), compared to 1.6 uM for FK 3311 (COX-2 Inhibitor V). Antiinflammatory activity was assessed by inhibition of adjuvant-induced arthritis, and analgesic activity was determined in the acetic acid-induced writhing assay. Following p.o. administration of 10 mg/kg, racemic (2) and its optical isomers showed activity comparable to FK-3311 (76% inhibition) in the adjuvant arthritis test, whereas racemic (5) showed very weak activity, and (R)- and (S)-(5) were not tested. With regard to analgesic effects, FK-3311 and racemic (2) showed 81 and 62% inhibitions, respectively, at a dose of 100 mg/kg p.o. The (R)- and (S)-isomers of (2) and racemic (5) all showed 46% inhibition of writhing syndrome. (R)- and (S)-(5) were less active showing 16 and 20% inhibitions, respectively.

體內(nèi)研究

L-PVR, CO, PaO(2), and WDR were significantly better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly reduced. Two-day survival rate was significantly better in the FK group than in the control group.
Survival rate was significantly better and serum GOT levels 30 min after reperfusion were significantly lower in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control.

"116686-15-8" 相關(guān)產(chǎn)品信息
616-91-1
铜山县| 拉萨市| 凤翔县| 元谋县| 寿宁县| 开封市| 巫山县| 茶陵县| 汤阴县| 富锦市| 兴海县| 渝北区| 凌海市| 两当县| 栾川县| 河间市| 香河县| 年辖:市辖区| 泸水县| 武宁县| 龙井市| 双牌县| 突泉县| 封开县| 长武县| 迁西县| 茌平县| 黔东| 靖江市| 团风县| 楚雄市| 乌恰县| 泰兴市| 上栗县| 芦溪县| 社旗县| 武隆县| 蒙自县| 历史| 拜城县| 华坪县|