1169211-37-3
中文名稱
化合物 CFI-400437
英文名稱
2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-
CAS
1169211-37-3
分子式
C29H28N6O2
分子量
492.57
MOL 文件
1169211-37-3.mol
1169211-37-3 結(jié)構(gòu)式
基本信息
英文別名
2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-物理化學(xué)性質(zhì)
沸點794.3±60.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)12.17±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4.