1185241-83-1
中文名稱
化合物TESMILIFENE FUMARATE
英文名稱
DPPE FUMARATE
CAS
1185241-83-1
分子式
C30H28O4P2
分子量
514.49
MOL 文件
1185241-83-1.mol
1185241-83-1 結(jié)構(gòu)式
基本信息
中文別名
化合物TESMILIFENE FUMARATE 英文別名
DPPE FUMARATETesmilifene fumarate
N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE
inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor
物理化學(xué)性質(zhì)
儲(chǔ)存條件Desiccate at -20°C
溶解度Soluble to 100 mM in sterile water
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
Tesmilifene fumarate (DPPE fumarate) 是 H1C 受體的拮抗劑，可廣泛的增強(qiáng)化療的細(xì)胞毒性，并保護(hù)正常細(xì)胞。體外研究
Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy.
體內(nèi)研究
Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants.
| Animal Model: | Male BKTO mice (25-45 g). |
| Dosage: | 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). |
| Administration: | S.C. and icv. |
| Result: | Potentiated seizures induced by both convulsants. |