118908-07-9
英文名稱
5-ethynyl-1-ribofuranosylimidazole-4-carboxamide
CAS
118908-07-9
分子式
C11H13N3O5
分子量
267.24
MOL 文件
118908-07-9.mol
118908-07-9 結構式
基本信息
英文別名
5-ethynyl-1-ribofuranosylimidazole-4-carboxamide1H-Imidazole-4-carboxamide, 5-ethynyl-1-β-D-ribofuranosyl-
應用領域
用途一
EICAR is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. It is a nucleoside derivative which has both anti-cancer and antiviral effects, and was originally developed for the treatment of leukemia, but was unsuccessful in human clinical trials. It has broad spectrum antiviral effects with activity against vaccinia virus, Semliki forest virus, Junin virus, reovirus, influenza, measles virus and respiratory syncytial virus among others, although it is not active against SARS. This useful spectrum of activity means that EICAR and related derivatives continue to be investigated for the treatment of viral diseases.