1191911-26-8
中文名稱
CZC25146
英文名稱
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
CAS
1191911-26-8
分子式
C22H25FN6O4S
分子量
488.54
MOL 文件
1191911-26-8.mol
更新日期
2026/07/27 12:22:37
1191911-26-8 結(jié)構(gòu)式
基本信息
中文別名
CZC-25146游離態(tài)N-(2-((5-氟-2-((2-甲氧基-4-嗎啉基苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酰胺
英文別名
CZC-25146CHEMBL2397014
LRRK2 Inhibitor II
LRRK2 INHIBITOR II
CZC25146
CZC 25146
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)697.4±65.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,2-8°C
儲(chǔ)存條件under inert gas (nitrogen or Argon) at 2-8°C
溶解度≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
酸度系數(shù)(pKa)8.48±0.10(Predicted)
形態(tài)固體
顏色Pale purple to purple
應(yīng)用領(lǐng)域
用途1
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons鈥檚 disease, and is ATP-competitive.